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Our laboratory shown that SERT and αvβ3 receptors colocalize in midbrain presynaptic terminals (Mazalouskas et al., 2015), suggesting that SERT is localized to multiprotein complexes coordinated by integrin αvβ3 in midbrain synapses. Prior research counsel that in platelets, the association of SERT with activated αIIbβ3 integrins, and its localization to adhesion complexes, are correlated with enhanced uptake action (Carneiro et al.
Significant genotype distinctions in the quantity of synapses are indicated in italics. Structured illumination microscopy of WT and KI midbrain slices was used to quantify the colocalization from the detailed proteins inside of SERT-constructive synapses.
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max) that did not outcome from decreased plasma membrane expression, reduced potency, or binding potential of your transporter. We also observed reductions in the amount of 5-HT synapses within the midbrain, Even though no changes in SERT protein concentrations were being noticed in tissue or synaptosomes isolated from KI mice when put next with WT preparations, indicating compensatory results at the neuron amount.
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